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Our experience suggests that problems in the watermaze such as thigmotaxis and passive floating are minimized if mice first get accustomed to being removed from their home cage to solve relatively unthreatening problems, before being placed in a large tank of water with no visible means of escape

GHK-Cu vs NAD+ for Anti-Aging: Where the Evidence Actually Stands Neither therapy has large-scale, long-term randomized controlled trial data in humans for anti-aging endpoints specifically

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But it also explains why transition periods can look like worsening