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FIGURE 1 2 Combination therapy with 5-ASA and TCM for UC 2.1 Combination of natural bioactive compounds with 5-ASA: multidimensional regulation and delivery enhancement The combination of natural bioactive compounds with 5-ASA represents a significant advancement in UC therapy, aligning with the emerging trend toward multi-target regulation and synergistic efficacy

For instance, IFRD1 knockout combined with CB-839 treatment effectively inhibited the low-cost survival of tumor cells under nutrient stress in HCC animal models by blocking the autophagic degradation pathway of histone H1.0 (164)

To provide rapid symptomatic relief while the methotrexate takes effect, a bridging therapy of low-dose oral prednisone (5 to 10 mg daily) was prescribed, with a plan to taper off within four to six months (Cohen & Mikuls, 2025)

Because the recombinant proteins were designed to function independently of platelets and contain no motifs that directly bind them their presence did not have significant effects on platelet aggregation (Supplementary Fig

Astrocyte support for oligodendrocyte differentiation can be conveyed via extracellular vesicles but diminishes with age