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doi: 10.1093/nar/gkae973 Summary Keywords cuproptosis, ferroptosis, nano-drug delivery systems, oral squamous cell carcinoma, programmed cell death Citation Ma X, Chen Y, Mai H, Lai P, Alimujiang A and Lu M (2026) From molecular crosstalk to precision therapy: targeting ferroptosis and cuproptosis in oral squamous cell carcinoma

For instance, a study demonstrated that blocking MCU significantly reduced ROS production and mitochondrial swelling in iron-overloaded thalassemic mice, suggesting that MCU could be a therapeutic target for preventing mitochondrial dysfunction in IOC ( Genetics factors Polymorphisms and mutations in specific genes can participate in cardiac iron overload

Fois AG, Paliogiannis P, Sotgia S, Mangoni AA, Zinellu E, Pirina P,

It also partly overlaps with the endoplasmic reticulum and Golgi