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Interactive relationships and protein-protein interaction (PPI) networks of the overlapping DEGs were evaluated using the STRING database ( (www.proteomaps.net) based on RNA transcript data were drawn to visualise three levels of functional categories based on KEGG pathway analysis (www.genome.jp/kegg/) ( Analysis of immune cell infiltration and the glandular microenvironment The cell type of each cluster (43 immune cells and 8 salivary glandular compositions) was identified using the CellMarker database and by aligning marker genes to known signature genes reported in previous studies ( The single-sample gene set enrichment analysis (ssGSEA) ( algorithms were used to estimate the proportion of innate and adaptive immune cell types in the LSGs of patients with pSS

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This oxidative stress leads to lipid peroxidation, protein oxidation, and mitochondrial DNA damage