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Since skin steroidogenesis can be modulated by external factors and is locally restricted, there is a tremendous potential for novel topical therapeutic approaches targeting skin estrogen biosynthesis to achieve local estrogen healing benefits without off-target effects which are undesirable in both men and women, as explained in the following section

In addition, it was previously demonstrated that HS02-52G aptamer binds to APC in a Ca 2+ -dependent manner 26

Animal models are the main tool to investigate etiology, molecular mechanisms and screening for pharmacological therapies