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Kelley RK, Verslype C, Cohn AL, Yang TS, Su WC, Burris H, et al

This study successfully identified C5 and SCP2 as promising drug targets through Mendelian randomization and Bayesian colocalization, and highlighted beta-Amyrone as a potential dual-target inhibitor with strong binding affinity to both proteins, paving the way for innovative treatment strategies

Although inexpensive and easy to carry out, this method is only able to detect cases with 20% or less of mean normal G6PD activity and misses most of the moderate G6PD activity especially in female heterozygotes (4)

Omaha: University of Nebraska Medical Center

Some of the prototypical enzyme inducers cause an initial and transitory mitogenic response that increases the number of hepatocytes in the affected liver (Bentley et al