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Nat Commun 9(1):3001 Cao G, Jiang N, Hu Y, Zhang Y, Wang G, Yin M et al (2016) Ruscogenin attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway

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J Am Heart Assoc (2019) 8(9):e011955

Munoz JF, Gallo JE, Misas E, Priest M, Imamovic A, et al

Activation in the area postrema (AP) The area postrema is a circumventricular organ , a region of the brain that has no blood-brain barrier , so peptide hormones from the blood have direct access to it