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Blood-brain barrier dysfunction, status epilepticus, seizures, and epilepsy: a puzzle of a chicken and egg

Since most studies did not include depression/anxiety patients of the same severity, it was difficult to conduct subgroup analysis based on baseline disease severity

doi: 10.1038/nprot.2006.378 34 KarpuzogluEFenauxJBPhillipsRALengiAJElvingerFAnsar AhmedS

See representative reviews and trials for context: a randomized trial protocol and review, a review summarizing silymarin's metabolic effects (ScienceDirect review), and recent supplementation analyses reporting trial outcomes

Chem Res Toxicol 12: 521525 Gallogly MM, Starke DW, Leonberg AK, Ospina SM, Mieyal JJ (2008) Kinetic and mechanistic characterization and versatile catalytic properties of mammalian glutaredoxin 2: implications for intracellular roles