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Once bound, the antibody and the linked drug are both pulled into the cell, delivering a toxic payload that maximizes the damage to cancer cells while sparing healthy normal cells: Ado-trastuzumab emtansine (T-DM1/Kadcyla ) was FDA approved in 2013 for the treatment of adults with HER2-positive metastatic breast cancer who previously received Herceptin and a taxane, separately or in combination

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