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Een veelgeciteerde review in het Journal of Neurochemistry (Kovalzon en Strekalova, 2006) noemt DSIP letterlijk "a still unresolved riddle" (een nog onopgelost raadsel) en concludeert dat de hypothese van DSIP als slaapfactor slecht onderbouwd en zwak blijft, mede door het ontbreken van een geidentificeerd DSIP-gen en een specifieke receptor

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During the 24-week treatment period, mean best-corrected visual acuity significantly improved at 0.4 (95% CI: 0.20.6, P 0.001), and 0.2 (95% CI: 0.020.4, P = 0.03) letters/month in cohorts 1, 2, and 3, respectively