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In the SURPASS clinical trial program in type 2 diabetes mellitus (T2D), tirzepatide was associated with unprecedented reductions in HbA1c, clinically significant weight loss and other metabolic benefits, combined with low rates of hypoglycaemia across a wide range of patient characteristics

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Continuous oxidative damage to mtDNA has been linked to aging, inflammation, carcinogenesis, and the development of malignancy [47]