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The two regulatory frameworks have different evidentiary standards and different scope of allowed claims

This downregulation turns out to be responsible for low sugar uptake and in turn for BBB breakdown, worsening AD cerebrovascular degeneration, neuropathology and cognitive functions (Winkler et al., 2015)

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Together, these findings provide compelling evidence that oxidative stress plays a critical role in the pathophysiology of depression and may represent both a biomarker of disease severity and a potential target for therapeutic intervention through modulation of antioxidant defenses (3537)