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For example, several studies using proton magnetic resonance spectroscopy have reported reduced levels of N -acetyl aspartate, a marker of impaired mitochondrial energy production, in the brains of bipolar disorder patients compared with healthy controls [121,122,123,124,125]

Mhamdi et al., 2010

The negative surface charge was attributed to deprotonation of carboxyl and phenolic groups in the plant extract, which acts simultaneously as a reducing and capping agent during nanoparticle formation 74

Then there's the other side of the coin

Habitat fragmentation, vehicle and animal collisions, and habitat destruction are all leading to a decline in mammalian populations