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402 Resveratrol protects the heart from I/R injury and cardiomyopathy through multiple mechanisms, such as scavenging free radicals, reducing myocardial oxygen demand, inhibiting inflammation-induced damage, inducing angiogenesis, improving mitochondrial function, and preventing cardiomyocyte apoptosis

In in vitro assays using peripheral blood mononuclear cells from patients with AS, it was demonstrated that cryptotanshinone and tanshinone IIA, the main compounds of SMR, significantly reduced the protein expression levels of COX-2, IL-6, and TNF-

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This process might begin with a deficient CD4 T-cell response to viral infections in genetically predisposed individuals (HLA-DRB1), followed by an uncontrolled immune response with CD8 T-cell hyperactivation and elevated antibody production, some of which may be directed against autoantigens, which can trigger autoimmune hypophysitis or direct damage to the pituitary, resulting in decreased production of pituitary hormones, such as ACTH