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[39] (2011) reported a favorable reduction in IHLC after a hypocaloric LCD (8% carbohydrates [C], 33% protein [P], 59% fat [F]) compared to a hypocaloric diet (50% C, 16% P, 34% F), as did Kirk et al

PNPLA3, Patatin-like Phospholipase Domain Containing 3

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Furthermore, clinical investigations have revealed that the high level of TMAO is linked to an augmented likelihood of unfavorable renal outcomes, including deterioration in renal function and mortality in individuals with kidney disorders ( While significant evidence connects TMAO to kidney disease, the exact mechanisms of how it causes kidney injury remain unclear