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In ovarian stromal cells of PCOS patients, LH enhances CYP17A1 phosphorylation via the cAMP/PKA pathway, upregulating 17-hydroxylase and 17,20-lyase activities and leading to excessive production of androstenedione and testosterone (58)

Kidney stones Because oxalate is a metabolite of vitamin C, there is some concern that high vitamin C intake could increase the risk of calcium oxalate kidney stones

Preclinical studies showed great effects of cold pulsatile perfusion vs static storage due to amelioration of endothelial function and reduced pathological lesions within renal parenchyma (139)

Hydrate: Drink a full glass of water with your supplement to support overall cellular function

This is why practitioners often recommend starting with a lower dose and gradually titrating up to the full 6 capsules per day, allowing the body's elimination pathways time to adjust to the increased toxic load