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The FDA does not require pre-approval for cosmetic ingredients, which is why thousands of serums, creams, and prescription formulations contain it without regulatory issue

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Toret, D

This is evident in IBDs such as Crohns whereby patients have been reported to express receptor variants to IL-23, a cytokine primarily expressed by macrophages and found in elevated abundance in the intestinal mucosa of Crohns patients (Duerr et al