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Each of these three isoforms of apoE has a different composition of two specific amino acid residues, 112 and 158: apoE2 has Cys in both these residues, whereas apoE3 has Cys in residue 112 and positively charged Arg in residue 158 and apoE4 has Arg in both residues 112 and 158

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Lutful Kabir F, Ambalavanan N, Liu G, Li P, Solomon GM, Lal CV, Mazur M, Halloran B, Szul T, Gerthoffer WT, Rowe SM, Harris WT (2018) MicroRNA-145 antagonism reverses TGF-beta inhibition of F508del CFTR correction in airway epithelia

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Indoxyl sulfate predicts cardiovascular disease and renal function deterioration in advanced chronic kidney disease