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The effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress among women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials

Thus, glutamatergic excitotoxicity through the kynurenine pathway and related pathways may be a key mechanism by which stress leads to the neurophenotypes commonly identified in depression, including gray matter loss (as measured by smaller limbic volumes, cortical thinning, and lower surface area), lower integrity of white matter microstructure in fronto-cingulate-limbic tracts (LeWinn et al., 2014), and altered intrinsic fronto-cingulate-limbic connectivity (Ho et al., 2014, 2015, 2017b

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The study also noted a higher risk of hyperpigmentation in the copper peptide group compared to dermaroller alone

It loses its structural integrity through oxidative damage and inadequate repair signaling