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Anticancer Res (2018) 38:608590

HMGCR Is Necessary for the Tumorigenecity of Esophageal Squamous Cell Carcinoma and Is Regulated by Myc

Finally, we are studying a largely unstructured region from MBD2, which is necessary and sufficient for binding and recruiting other components of the NuRD complex.7 Ultimately the goal of these studies is to understand the structural mechanism of methylation dependent gene silencing by MBD2 and to develop inhibitors of complex formation for therapeutic benefit