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For people in chronic states of nervous system dysregulation whether from ongoing life stressors, unresolved trauma, or a condition like mast cell activation syndrome (MCAS) this pathway can be a dominant driver of histamine overload

doi: 10.1016/j.tem.2013.04.002 44 SaitoMOkamatsu-OguraYMatsushitaMWatanabeKYoneshiroTNio-KobayashiJet al

Surg Pathol Clin 14(2):177-194, 2021

It has been demonstrated that WECP treatment activated the phosphorylation of Akt and glycogen synthase kinase-3-beta (GSK3), promoted -Catenin and Wnt10b accumulation, and upregulated the expression of lymphoid enhancer-binding factor 1 (LEF1), vascular endothelial growth factor (VEGF), and insulin-like growth factor 1 (IGF1)

Conversely, co-treatment with DAPA resulted in a mild NF-B p65 immunoreactivity, which was observed in a limited number of cytoplasmic and nuclear compartments of pyramidal cells within the CA1 region of the hippocampus ( Fig