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Often times, the impurities are highly similar to the desired product, making chromatographic separation difficult and likely time consuming

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Early observational data and clinical experience suggest GLP-1s do not typically trigger or exacerbate ulcerative colitis flares, though individual gut microbiome composition and disease severity may influence tolerability and symptom response

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Insufficient intrinsic factor production, common in older adults due to age-related absorption decline, can also lead to deficiency