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A hydrophobic tunnel of MmaA4 (residues 180 to 216, called 2-3 motif) protrudes from the protein surface to the cofactor binding site and covers 2 and 3 helices, and the sequence connecting 3-E displaying the same basic/hydrophobic patches as other SAM-MTs [136, 138]

To prevent major seizures, valproate should not be discontinued abruptly, as this can precipitate status epilepticus with resulting maternal and fetal hypoxia and threat to life