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Even if a fraction of the active ingredient reaches the small intestine intact, its absorption is often severely restricted due to unfavorable molecular size, poor intestinal permeability, and extensive hepatic first-pass metabolism

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While these ingredients can help with brightening, they typically work more slowly than glutathione formulations

Binding was visualized by addition of TMB substrate (Calbiochem) or AP-substrate (Merck) (10 g/mL in diethanolamine buffer)