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The reason: prolonged continuous exposure downregulates IGF-1 receptor density (receptor desensitization)

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Fat Metabolism Stimulates lipolysis , breaking down triglycerides in adipose tissue Reduces fat mass, especially visceral fat 3

doi:10.1152/ajpendo.00201.2006 Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ

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