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This work has led to the suggestion that sulfated neurosteroids must be transported from the periphery into the CNS, but this hypothesis has not been validated (186)

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These molecules are carried across the barrier thanks to transporter proteins present in the cerebral capillaries

Mechanistic investigations associate these outcomes with signaling pathways involving vascular endothelial growth factor receptor-2 (VEGFR-2) and downstream Akt-eNOS activation, processes that collectively facilitate efficient muscle tissue remodeling (5)

The largest study in humans is an exploratory analysis of the REWIND trial, evaluating the effect of dulaglutide vs