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With high glucose availability, estrogen upregulates glycolysis and suppresses the TCA cycle, whereas, under glucose deprivation conditions, it inhibits glycolysis and promotes the TCA cycle by activating pyruvate dehydrogenase (PDH) to ensure cellular survival [41]

Evening administration aligns with natural GH secretion patterns but is not strictly required for effectiveness

Rohatgi PR, Swisher SG , Correa AM, Wu TT, Liao Z, Komaki R, Walsh G, Vaporciyan A, Lynch PM, Rice DC, Roth JA, Ajani JA

Liberman AC, Budziski ML, Sokn C, Gobbini RP, Steininger A, Arzt E