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24 A systematic review of pramipexole in TRD revealed a mean maximum pramipexole dose between 0.69 and 2.18 mg/day

doi: 10.1016/j.neuint.2023.105646 34 MaasA

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Research using Morris water maze (spatial memory), passive and active avoidance (fear-motivated learning), novel object recognition, and operant conditioning tasks shows that Semax improves acquisition, consolidation, and retrieval of memory in both normal animals and those with experimentally induced cognitive impairment

In rat models of PD, IN DFO has been reported to protect dopaminergic neurons in the substantia nigra and ameliorate motor deficits, suggesting IN DFO reaches the midbrain regions at pharmacologically active concentrations (Febbraro et al., 2013)