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Similarly, Gly-Leu-Pro, an ACE inhibitory peptide from chum salmon skin gelatin, exhibited an antihypertensive effect in spontaneously hypertensive rats, reducing systolic blood pressure by 31 mmHg after 6 h at a dosage of 20 mg/kg [141], suggesting that it could serve as a promising natural alternative for the development of functional foods aimed at controlling hypertension

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Complementary to these nuclear genetic adaptations, mitochondria, as central hubs for energy metabolism and redox balance, are essential for hypoxic survival [12]