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Description

45 This therapeutic effect was associated with the normalization of autophagy-related markers (macroautophagy and chaperone-mediated autophagy) and reduced expression of pro-inflammatory mediators

Multiple therapeutic approaches that target CD38 in multiple myeloma, melanoma and other CD38-associated malignancies are currently investigated, with the prevailing mechanism attributed to antibody-mediated cytolysis and phagocytosis 21