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Oxidative stress is implicated in the pathophysiology of all factors causing COVID-19 and post-COVID-19 symptoms

Moreover, treatment of CC mice with NA rescued NAD + levels in skeletal muscle, improved muscle function, and increased Oxphos complexes expression, yet NA treatment had no effect on mitochondrial respiration 248

It presents a significant diagnostic and therapeutic challenge due to its varied clinical manifestations and overlap with other liver diseases, as, for instance, primary biliary cholangitis or primary sclerosing cholangitis