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doi: 10.1016/j.jdermsci.2019.05.003 51 MesitskayaDFSyrkinALAksenovaMGZhangYZamyatninAAJrKopylovPY

These are perhaps best exemplified by the mucolytic agent dornase alfa (recombinant human DNase), which is widely used and effective in CF but has been shown to be ineffective and possibly detrimental in non-CF bronchiectasis