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[6] Sigma-Aldrich SML2832 5-Amino-1-methylquinolinium iodide technical page

Joint pain developing after starting B12 may reflect: Pre-existing musculoskeletal conditions becoming more noticeable Concurrent inflammatory or degenerative joint disease Reactions to excipients in certain formulations The natural course of an underlying condition If you experience persistent or worsening joint symptoms after beginning B12 supplementation, it is advisable to consult your GP or healthcare provider

PMCID: PMC4772032

Research is restricted to controlled laboratory environments

Older adults, as well as those with digestive issues or who are vegan or vegetarian, could struggle with B12 deficiencies