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PMCID: PMC6770181.

PMID: 29155147): 5-Amino-1MQ showed NNMT selectivity with IC50 of 1.2 microM Reduced body weight and white adipose mass in diet-induced obese mice over 11 days No effect on food intake, suggesting metabolic rather than appetitive mechanism Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice , published in Scientific Reports (Dimet-Wiley AL et al., 2024

Drugs known to inhibit prostaglandin synthesis and release (increase the incidence of early closure of patent ductus arteriosus) are not recommended

Any protective effect likely comes from general cellular resilience rather than direct anti-androgenic action

Tabk AG, Herder C, Rathmann W, Brunner EJ, Kivimki M