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Farebrother J, Zimmermann MB, Andersson M

In addition, A53T and A30P -syn exhibit a stronger binding affinity for the lysosomal receptor LAMP2A compared with wild-type (WT) -syn, so these mutant forms of -syn are not efficiently degraded by protein clearance mechanisms, which results in increased -syn burden of chaperone-mediated autophagy and inhibits the loading and clearance of other cargo (Cuervo et al., 2004)

doi: 10.1126/science.1233158

2: Acetyl-L-Carnitine Alpha-GPC

Piperine targets different drug resistance mechanisms in human ovarian cancer cell lines leading to increased sensitivity to cytotoxic drugs