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doi: 10.1007/s10815-008-9212-7

10.1016/j.plefa.2017.03.006 315

Mechanisms Ageing Dev

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Although the signaling pathways leading to the progression of apoptosis have been extensively characterized, recent studies highlight the regulatory role of changes in the intracellular milieu (permissive apoptotic environment) in the efficient activation of the cell death machinery