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In conclusion, the pathological features and pathogenic factors of PD include the excessive accumulation of -Syn in the substantia nigra pars compacta or its gene mutation

Accordingly, the observed changes reflect alterations in the abundance and signaling activity of the combined M/M population, and the term activation is used operationally to denote increased CD11b-positive cell density accompanied by enhanced pain-related signaling rather than morphology-defined activation states