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SDF-1/CXCR4 axis facilitates myeloid-derived suppressor cells accumulation in osteosarcoma microenvironment and blunts the response to anti-PD-1 therapy

The findings demonstrated a significant increase in ROS levels across all three antibiotics, as well as in the positive control, hydrogen peroxide

With a series of differentially expressed genes identified, we found that the expression of ERG1, the chemokines CXCL2 and CXCL8, and the inflammatory factors IL-6 and IL-1 in the medication group was significantly increased (Fig

However, due to the antioxidant defense mechanism in tumor cells, the upregulated antioxidant glutathione [62] (GSH) directly consumes the ROS generated during the photo-chemotherapy process triggered by light activation [63], This thereby affects the release of the prodrug and reduces the therapeutic effect [64]

doi: 10.31557/APJCP.2024.25.7.2271 106 JinBWanSBoahMYangJMaWLvMet al