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Cystine restriction rescues glutamine-addicted TNBC cells from glutamine deprivation by restoring intracellular TCA cycle intermediates Given that TNBC cells exhibit heightened reliance on extracellular glutamine due to enhanced glutamine anaplerosis, we next investigated whether this phenotype is linked to an increased dependence on extracellular cystine

3a), which contrasts with the lack of effect in HEK293T cells (Fig

The blank control group, positive control group, and experimental groups were supplemented with 20 L of MRS medium, clindamycin at the final concentration of 20 g/mL [24], various probiotic solutions (OD 600nm = 1), and LP-EVs at the final concentration of 200 g/mL, respectively

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