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Regionally specific susceptibility may be due to the proximity of the medial rostral corpus callosum to the subventricular zone, as neural precursor cells from the subventricular zone migrate into the proximal rostral corpus callosum by week 3 of cuprizone administration, where they can dampen the inflammatory response and differentiate into mature oligodendrocytes 26,51,52,53

The retrospective nature of the study and absence of randomization increase the risk of selection and measurement bias, p

doi: 10.1016/0888-7543(95)80021-d