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Ethical considerations, such as the use of anaesthesia and euthanasia methods in advanced embryos, urge the application of the 3Rs principle (Replacement, Reduction, Refinement) and the development of protocols to ensure embryo and hatchling welfare and the responsible use of these organisms

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The decreased secretory response to Ca2+ observed in nodular uremic hyperplasia may be explained by the markedly reduced CaSR expression in CKD, as demonstrated by Gogusev et al (94)

10.1016/j.bbadis.2018.11.015 73 MalyukovaA.LahnalampiM.Falqus-CostaT.PlnenP.SipolaM.MehtonenJ.et al (2024)