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Contrary, NP4 showed a cytotoxic effect in the very low micromolar range (143B: IC 50 = 6.6 M, K7M2: IC 50 = 2.1 M) (drug-response curves: Fig

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Curcumin is an effective therapeutic compound, because it controls many important pathways of molecular signaling which in turn modulate the survival and pathways that govern anti-oxidative factors (such as nuclear factor E2-related factor 2, Nrf2) and inflammatory responses like nuclear factor kappa B (Hatcher et al., 2008)

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Analysis of inflammation-related parameters showed that PX-478 significantly elevated mtDNA-mediated inflammatory responses, as indicated by increased levels of inflammation markers in M9a+sh EPAS1 cells (Fig