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The GABA(B) receptor blockers increase active brain states such as when were awake or in REM sleep (dreaming stage) [46]

In intestinal epithelial cells, this enhanced contractile tension induces centripetal contraction of the perijunctional actomyosin ring, leading to internalization and reorganization of junctional proteins, including claudins, occludin, ZO-1, and adherens junction components, resulting in reversible TJ opening and increased paracellular permeability