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LR3 IGF-1 is a modified analog of human IGF-1 with a 13-amino acid extension at the N-terminus and a substitution of Arg at position 3, which significantly reduces its affinity for IGF-binding proteins

Meanwhile, L-carnitine enhanced mitochondrial -oxidation activities and the expression of carnitine palmitoyltransferase 1 mRNA significantly, whereas it depressed the mRNA expression of adipogenesis-related genes

The enhanced fat oxidation capacity matters most when there is a metabolic demand for it, and physical activity creates that demand much more effectively than caloric restriction alone

Acetylcholinesterase (AChE) Activity The activity of AChE was detected according to Ellman et al (1961)