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The cells were then divided into two groups for further treatment: one group served as the control and was treated with Lipofectamine LNP, while the other group was targeted for PGC-1 interference using siRNA lipid complex (si-PGC-1 LNP)

doi: 10.1038/s41598-019-49383-8

Furthermore, we found that AAV- Ksp - Usp2 transfection reversed the reduction of kidney fibrosis and ferroptosis in Usp2 KO UUO mice