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The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death

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Additionally, studies have shown that gram-negative bacteria/LPS can induce the production of TLR4-dependent CXCL1 in hepatocytes, which induces CXCR2 + PMN-MDSCs infiltrating in TME, thereby regulating the formation of an immunosuppressive microenvironment in hepatocytes and promoting liver tumor growth [736]

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