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For drug resistance regulation, metabolic reprogramming mediated by SSP activation represents a common mechanism underlying chemoresistance and targeted therapy resistance across pan-cancer

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This just-formed superoxide, together with its reduced metabolites, can interact with a great number of different naturally occurring body biomolecules, at least partially leading to the development of many diseases such as cardiovascular disease, cancer, chronic inam- mation, dementia, and amyotrophic lateral sclerosis, among others [ 140 , 141 ]

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