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201 A meta-analysis that reported findings from 23 randomized controlled trials involving 842 participants with stage 35 CKD indicated that probiotic, prebiotic, and synbiotic supplements improved creatinine and BUN levels, heightened markers of oxidative stress, reduced some markers of inflammation, and decreased uremic toxin levels

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In Alzheimers disease, PHGDH upregulation, an upstream control point in the serine synthesis pathway, supports the idea that disrupted serine metabolism is coupled to persistent neuroinflammatory signaling 73