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An important theme in interpreting vitamin B 12 deficiency is the remethylation block hypothesis: Vitamin B 12 deficiency results in hyperhomocysteinemia because Hcy remethylation is blocked (Selhub et al., However, a further examination of this hypothesis, for example using the topology of the metabolic network in Figure 1, shows there might be difficulties with this interpretation

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You can either shout the song louder (= more GH), or increase the sensitivity of the radio so it picks up weaker signals (= more receptors)

depleted sod-C (sodC) mutant and sodC mutant with attenuated sod-B gene expression (sodB sodC) exhibited attenuated intracellular survival in IFN--activated macrophages compared to the wild-type LVS