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[DOI] [PMC free article] [PubMed] [Google Scholar] [85].Sharma A, Yuen D, Huet O, Pickering R, Stefanovic N, Bernatchez P, de Haan JB, Lack of glutathione peroxidase-1 facilitates a pro-inflammatory and activated vascular endothelium

Additionally, proteolysis targeting chimeras (PROTACs) offer a novel approach to modulate ferroptosis: PROTACs targeting ACSL4 or Nrf2 have been developed to either induce ferroptosis (in renal cell carcinoma) or enhance antioxidant defense (in CKD), respectively, with improved specificity compared to small-molecule inhibitors

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Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2

The Core Benefits of Glutathione: What the Research Shows Powerful Antioxidant Protection Glutathione is often called the master antioxidant because it doesnt just neutralize free radicalsit also regenerates other antioxidants like vitamins C and E